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Factor VIII in vitro bioequivalence of denecimig (Mim8) hemostatic effect by thrombin generation assays

Background: Denecimig (Mim8, Novo Nordisk A/S) is a next-generation bispecific antibody designed to mimic activated factor (F)VIII and restore hemostasis in persons with hemophilia A. The extent to which activated FVIII mimetics, such as denecimig and emicizumab, can correct clotting deficiency rema...

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Principais autores: Jacob Lund, Mirella Ezban, Kasper Jensen, David Lillicrap
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2026-01-01
סדרה:Research and Practice in Thrombosis and Haemostasis
נושאים:
bioequivalence
bispecific antibodies
factor VIII
hemophilia
thrombin
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2475037925006570
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