Pervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase

Abstract F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, the DNA damage response, and gliom...

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Auteurs principaux:	Hongbin Yang, Paul Smith, Yingying Ma, Emily Southworth, Varun Gopala Krishna, Beatrice Salerno, Joseph Rowland, Alexander E P Loftus, Domenico Grieco, Iolanda Vendrell, Roman Fischer, Benedikt M Kessler, Vincenzo D’Angiolella
Format:	Artigo
Langue:	Inglês
Publié:	Springer Nature 2026-01-01
Collection:	The EMBO Journal
Sujets:	Ubiquitin F-box Proteins FBXO42 PP4 Phosphatase CRLs
Accès en ligne:	https://doi.org/10.1038/s44318-025-00675-y
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