NR2F6 deletion revives CAR-T cell function and induces antigen-agnostic immune memory in solid tumors

Abstract CAR-T cell therapy is effective in hematologic malignancies but remains challenging in solid tumors owing to antigen heterogeneity and tumor microenvironment-induced exhaustion. Here, gene editing of the nuclear receptor NR2F6 restores CAR-T cell functionality, sustaining a TCF1⁺ progenitor...

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Prif Awduron:	Dominik Humer, Victoria Klepsch, Dietmar Rieder, Isabel Hölzl, Daniel Schreiber, Viktor Lang, Jiří Koutník, Sebastian Peer, Tajana Sajinovic, Viana Wille, Anna Fürst, Dragana Savic, Gabriel Diem, Wilfried Posch, Ira-Ida Skvortsova, Anne Krogsdam, Sieghart Sopper, Sebastian Kobold, Zlatko Trajanoski, Kerstin Siegmund, Nikolaus Thuille, Thomas Gruber, Dominik Wolf, Gottfried Baier
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2026-02-01
Cyfres:	Nature Communications
Mynediad Ar-lein:	https://doi.org/10.1038/s41467-026-69796-0
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!