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Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.

FAcilitates Chromatin Transcription (FACT) is a complex of SSRP1 and SPT16 that is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT has been mostly studied in cell-free or single cell model systems because general FACT knockout (KO) is embryonically lethal (E3...

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Bibliografski detalji
Glavni autori: Poorva Sandlesh, Thierry Juang, Alfiya Safina, Michael J Higgins, Katerina V Gurova
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2018-01-01
Serija:PLoS ONE
Online pristup:https://doi.org/10.1371/journal.pone.0199785
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