Immunogenicity and antitumor efficacy of a novel human PD-1 B-cell vaccine (PD1-Vaxx) and combination immunotherapy with dual trastuzumab/pertuzumab-like HER-2 B-cell epitope vaccines (B-Vaxx) in a syngeneic mouse model

Therapeutic blockade of PD-1/PD-L1 signaling with monoclonal antibodies (mAbs) has shown clinical success and activity across a broad set of cancer subtypes. However, monotherapy with PD-1/PD-L1 inhibitors are only effective in a subset of patients and ongoing studies show efficacy of treatment depe...

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Principais autores:	Pravin T. P. Kaumaya, Linlin Guo, Jay Overholser, Manuel L. Penichet, Tanios Bekaii-Saab
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis Group 2020-01-01
Serija:	OncoImmunology
Teme:	immuno-oncology peptide cancer vaccines b-cell epitopes pd-1 pd-l1 nivolumab; ct26/her-2 model ct26 carcinoma her-2
Online dostop:	http://dx.doi.org/10.1080/2162402X.2020.1818437
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