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Protective mitochondrial fission induced by stress-responsive protein GJA1-20k

The Connexin43 gap junction gene GJA1 has one coding exon, but its mRNA undergoes internal translation to generate N-terminal truncated isoforms of Connexin43 with the predominant isoform being only 20 kDa in size (GJA1-20k). Endogenous GJA1-20k protein is not membrane bound and has been found to in...

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Principais autores: Daisuke Shimura, Esther Nuebel, Rachel Baum, Steven E Valdez, Shaohua Xiao, Junco S Warren, Joseph A Palatinus, TingTing Hong, Jared Rutter, Robin M Shaw
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2021-10-01
coleção:eLife
Assuntos:
GJA1-20k
mitochondria
actin dynamics
mitochondria dynamics
ischemia/reperfusion
organ protection
Acesso em linha:https://elifesciences.org/articles/69207
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