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Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae.

Regulation of PCNA ubiquitylation plays a key role in the tolerance to DNA damage in eukaryotes. Although the evolutionary conserved mechanism of PCNA ubiquitylation is well understood, the deubiquitylation of ubPCNA remains poorly characterized. Here, we show that the histone H2B(K123) ubiquitin pr...

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Autori principali: Alfonso Gallego-Sánchez, Sonia Andrés, Francisco Conde, Pedro A San-Segundo, Avelino Bueno
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2012-01-01
Serie:PLoS Genetics
Accesso online:https://doi.org/10.1371/journal.pgen.1002826
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