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Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae.

Regulation of PCNA ubiquitylation plays a key role in the tolerance to DNA damage in eukaryotes. Although the evolutionary conserved mechanism of PCNA ubiquitylation is well understood, the deubiquitylation of ubPCNA remains poorly characterized. Here, we show that the histone H2B(K123) ubiquitin pr...

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Auteurs principaux: Alfonso Gallego-Sánchez, Sonia Andrés, Francisco Conde, Pedro A San-Segundo, Avelino Bueno
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2012-01-01
Collection:PLoS Genetics
Accès en ligne:https://doi.org/10.1371/journal.pgen.1002826
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