Substance P–expressing neurons in the hypothalamic paraventricular nucleus mediate chronic cough hypersensitivity via the hypothalamus–airway neural pathway

Background and purposeIncreased cough sensitivity is the key pathophysiological mechanism of chronic cough. Although previous studies have focused on peripheral airway receptor sensitization, the role of the central nervous system—particularly the hypothalamic paraventricular nucleus (PVN)—remains u...

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Autores principales:	Xiaoyan Zhang, Jingyang Chen, Chun Lin, Tao Xiao, Bin Wu, Fei He
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-05-01
Colección:	Frontiers in Neuroscience
Materias:	cough hypersensitivity guinea pig model hypothalamic paraventricular nucleus neural pathway substance P
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fnins.2026.1816238/full
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