Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease

Bruton's tyrosine kinase (Btk) is a signaling molecule involved in development and activation of B cells through B-cell receptor (BCR) and Toll-like receptor (TLR) signaling. We have previously shown that transgenic mice that overexpress human Btk under the control of the CD19 promoter (CD19-hBtk) d...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Jasper Rip, Marjolein J. W. de Bruijn, Marjolein K. Appelman, Simar Pal Singh, Rudi W. Hendriks, Odilia B. J. Corneth
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2019-01-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	autoimmune disease B cell Bruton's tyrosine kinase phosphoflow cytometry Toll-like receptor
Онлайн хандалт:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00095/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!