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Targeting TRIM54/Axin1/β-Catenin Axis Prohibits Proliferation and Metastasis in Hepatocellular Carcinoma

Accumulating evidence demonstrates that dysregulation of ubiquitin-mediated degradation of oncogene or suppressors plays an important role in several diseases. However, the function and molecular mechanisms of ubiquitin ligases underlying hepatocellular carcinoma (HCC) remain elusive. In the current...

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Main Authors: Jinrong Zhu, Yongqi Wu, Shaoxi Lao, Jianfei Shen, Yijian Yu, Chunqiang Fang, Na Zhang, Yan Li, Rongxin Zhang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
TRIM54
ubiquitination
Wnt/β-catenin signaling
proliferation
metastasis
hepatocellular carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.759842/full
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