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Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

Abstract Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk factor for glaucoma and recent work has demonstrated critical early neuroinflammatory insults occur in the optic nerve head following ocular hypertension. Microglia and infiltrating monocytes are...

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Main Authors: James R. Tribble, Jeffrey M. Harder, Pete A. Williams, Simon W. M. John
Format: Artigo
Language:Inglês
Published: BMC 2020-05-01
Series:Molecular Brain
Subjects:
Glaucoma
Optic nerve head
Microglia
RNA-sequencing
DBA/2 J
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s13041-020-00603-7
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