FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life. To reach protective levels in fetuses, mAbs must be transported across the placenta, a selective barrier that actively and specifically promotes...

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Autori principali:	Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2024-12-01
Serie:	mAbs
Soggetti:	Antibody optimization entry inhibitor HIV leronlimab Mother-to-child transmission (MTCT) nonhuman primate
Accesso online:	https://www.tandfonline.com/doi/10.1080/19420862.2024.2406788
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