Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
Pranam Chatterjee et al. present a novel computational platform for engineering peptide fusions that bind to the SARS-CoV-2 spike protein and tag it for proteasomal degradation. They experimentally validate an optimal variant in human cells, showing that it inhibits production of infection-competent...
שמור ב:
| Principais autores: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Portfolio
2020-11-01
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| סדרה: | Communications Biology |
| גישה מקוונת: | https://doi.org/10.1038/s42003-020-01470-7 |
| תגים: |
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