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PFOA/PFOS induce ferroptosis in bladder epithelial cells through inhibition of ACSL4 ubiquitination

Introduction Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants, but their role in bladder epithelial injury remains unclear.MethodsSV-HUC-1 cells were exposed to PFOA and PFOS. Cell viability, lipid peroxidation, and ROS levels were assessed using CCK-8 ass...

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Principais autores: Hao Xu, Zhihua Ye, Juan Liu, Mengwei Liu, Qinghua Hu, Yi Liu, Qiankun Zhang, Jian Ou, Xin Shen, Xiaogang Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
Colecção:Frontiers in Toxicology
Assuntos:
ACSL4
bladder epithelial cell
ferroptosis
pfoa
PFOs
ubiquitination
Acesso em linha:https://www.frontiersin.org/articles/10.3389/ftox.2026.1774625/full
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