Assessment of genetic diversity of Plasmodium falciparum circumsporozoite protein in Sudan: the RTS,S leading malaria vaccine candidate

Abstract Background The currently used malaria vaccine, RTS,S, is designed based on the Plasmodium falciparum circumsporozoite protein (PfCSP). The pfcsp gene, besides having different polymorphic patterns, can vary between P. falciparum isolates due to geographical origin and host immune response....

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Principais autores:	Nouh Saad Mohamed, Hanadi AbdElbagi, Ahad R. Elsadig, Abdalla Elssir Ahmed, Yassir Osman Mohammed, Lubna Taj Elssir, Mohammed-Ahmed B. Elnour, Yousif Ali, Mohamed S. Ali, Omnia Altahir, Mustafa Abubakr, Emmanuel Edwar Siddig, Ayman Ahmed, Rihab Ali Omer
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2021-11-01
Series:	Malaria Journal
Assuntos:	Malaria Plasmodium falciparum circumsporozoite protein (PfCSP) Vaccine RTS,S Hapd N-terminal, central repeats, and C-terminal regions
Acceso en liña:	https://doi.org/10.1186/s12936-021-03971-0
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