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A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies

ABSTRACT Recent outbreaks of yellow fever virus (YFV) in West Africa and Brazil resulted in rapid depletion of global vaccine emergency stockpiles and raised concerns about being unprepared against future YFV epidemics. Here we report that a live attenuated virus similar to the Japanese encephalitis...

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Principais autores: Niraj Mishra, Robbert Boudewijns, Michael Alexander Schmid, Rafael Elias Marques, Sapna Sharma, Johan Neyts, Kai Dallmeier
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2020-04-01
סדרה:mBio
נושאים:
flavivirus
chimeric YFV-17D vaccine
chimeric flavivirus vaccine
cross-protection
dual protection
antibody-dependent enhancement
גישה מקוונת:https://journals.asm.org/doi/10.1128/mBio.02494-19
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