Decoding autoimmune disease with single-cell immune repertoire and transcriptome sequencing: mechanisms and therapeutic opportunities

Autoimmune diseases result from a breakdown of immune tolerance, driving the aberrant activation and clonal expansion of self-reactive T and B cells. Progress has been limited by the inability to link clonal identity to functional states at single-cell resolution. Single-cell T- and B-cell receptor...

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Hauptverfasser:	Shuqing Wang, Zhao Dong, Yuefang Liu, Xianhe Ren, Xin Wang, Hongsong Yu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-06-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	autoimmune diseases immunotherapy mechanisms single-cell TCR/BCR sequencing single-cell transcriptome sequencing
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1827384/full
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