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Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults in this signaling cascade are increasingly linked to cognitive disorders in humans, where increased GCPII and or dec...

Täydet tiedot

Tallennettuna:
Päätekijät: Dibyadeep Datta, Shannon N. Leslie, Elizabeth Woo, Nishita Amancharla, Ayah Elmansy, Miguel Lepe, Adam P. Mecca, Barbara S. Slusher, Angus C. Nairn, Amy F. T. Arnsten
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2021-11-01
Sarja:Frontiers in Aging Neuroscience
Aiheet:
NAALADase
FOLH1
mGluR3
GRM3
inflammation
2-MPPA
Linkit:https://www.frontiersin.org/articles/10.3389/fnagi.2021.760270/full
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