The Role of Conformational Dynamics and Allostery in the Control of Distinct Efficacies of Agonists to the Glucocorticoid Receptor

Glucocorticoid receptor (GR) regulates various cellular functions. Given its broad influence on metabolic activities, it has been the target of drug discovery for decades. However, how drugs induce conformational changes in GR has remained elusive. Herein, we used five GR agonists (dex, AZ938, pred,...

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Principais autores:	Yuxin Shi, Shu Cao, Duan Ni, Jigang Fan, Shaoyong Lu, Mintao Xue
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-07-01
coleção:	Frontiers in Molecular Biosciences
Assuntos:	glucocorticoid receptor allosteric communication allosteric site molecular dynamics simulation drug discovery
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.933676/full
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