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Embryonic Origin and Subclonal Evolution of Tumor-Associated Macrophages Imply Preventive Care for Cancer

Macrophages are widely distributed in tissues and function in homeostasis. During cancer development, tumor-associated macrophages (TAMs) dominatingly support disease progression and resistance to therapy by promoting tumor proliferation, angiogenesis, metastasis, and immunosuppression, thereby maki...

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Principais autores: Xiao-Mei Zhang, De-Gao Chen, Shengwen Calvin Li, Bo Zhu, Zhong-Jun Li
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-04-01
coleção:Cells
Assuntos:
tumor-associated macrophages (TAMs)
heterogeneity
origins
subclonal evolution
metabolism
cancer target therapy
Acesso em linha:https://www.mdpi.com/2073-4409/10/4/903
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