Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition

Mitochondrial fusion requires an alternating salt bridge between CMT2A-associated disease residues that enable GTP hydrolysis; Fzo1 ubiquitylation then licenses post-fusion recycling by Cdc48. Mitofusins are dynamin-related GTPases that drive mitochondrial fusion by sequential events of oligomerizat...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Vincent Anton, Ira Buntenbroich, Ramona Schuster, Felix Babatz, Tânia Simões, Selver Altin, Gaetano Calabrese, Jan Riemer, Astrid Schauss, Mafalda Escobar-Henriques
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Life Science Alliance LLC 2019-12-01
Цуврал:	Life Science Alliance
Онлайн хандалт:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.201900491
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!