Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition
Mitochondrial fusion requires an alternating salt bridge between CMT2A-associated disease residues that enable GTP hydrolysis; Fzo1 ubiquitylation then licenses post-fusion recycling by Cdc48. Mitofusins are dynamin-related GTPases that drive mitochondrial fusion by sequential events of oligomerizat...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Life Science Alliance LLC
2019-12-01
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| シリーズ: | Life Science Alliance |
| オンライン･アクセス: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.201900491 |
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