Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway

Malignant melanoma (MM) exhibits clinical traits of vigorous metastasis and an unfavorable prognosis. Traditional therapeutic modalities such as surgical resection, radiotherapy, and chemotherapy have restricted efficacy and notable side effects, thereby urgently demanding new drugs or treatment app...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Kong Jiahui, Zhang Yongqiang, Yang Yuchang, Wang Ziheng, Jing Xiaohong, Lin Shuting, Chen Hongyue, Dong Xiaoxv, Qu Changhai, Cai Mengru, Ni Jian, Yin Xingbin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-09-01
Schriftenreihe:	Journal of Science: Advanced Materials and Devices
Schlagworte:	Small interfering RNA Oridonin Metal-organic frameworks Tumor-targeted drug delivery system Biomimetic modification of cell membrane
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2468217925001108
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