Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Abstract Immune‐stimulating antibody conjugate (ISACs) incorporating STING agonists as payloads leverage both the targeting capability of the Fab region and the Fc region‐mediated tumor antigen‐dependent immune activation. Herein, a novel class of ISACs is reported, generated by engineering a quater...

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Principais autores:	Yu Long, Borui Tang, Fei Xie, Lianqi Liu, Yangyihua Zhou, Jingwen Dong, Jianfeng Wang, Cuicui Sun, Yuting Wang, Ruoqi Li, Na Zhang, Liping Li, Longlong Luo, Junhai Xiao, Wu Zhong, Dian Xiao, Hongbin Deng, Xinbo Zhou
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2025-08-01
Serija:	Advanced Science
Teme:	antitumor immunity diABZI STING agonist 3 immune‐stimulating antibody conjugates quaternary ammonium salt‐linker stimulator of interferon genes
Online dostop:	https://doi.org/10.1002/advs.202502270
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