A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear to what extent host genetic background influences response. To investigate this,...

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Principais autores:	Justin B. Hackett, James E. Glassbrook, Maria C. Muñiz, Madeline Bross, Abigail Fielder, Gregory Dyson, Nasrin Movahhedin, Jennifer McCasland, Claire McCarthy-Leo, Heather M. Gibson
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2022-12-01
Series:	OncoImmunology
Assuntos:	Immune checkpoint inhibitor genetic linkage analysis immunotherapy resistance melanoma prolactin diversity outbred
Acceso en liña:	https://www.tandfonline.com/doi/10.1080/2162402X.2022.2064958
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