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Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease

Abstract Background Prion disease is neurodegenerative disease that is typically fatal within months of first symptoms. Clinical trials in this rapidly declining symptomatic patient population have proven challenging. Individuals at high lifetime risk for genetic prion disease can be identified deca...

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Principais autores: Sonia M. Vallabh, Eric Vallabh Minikel, Victoria J. Williams, Becky C. Carlyle, Alison J. McManus, Chase D. Wennick, Anna Bolling, Bianca A. Trombetta, David Urick, Chloe K. Nobuhara, Jessica Gerber, Holly Duddy, Ingolf Lachmann, Christiane Stehmann, Steven J. Collins, Kaj Blennow, Henrik Zetterberg, Steven E. Arnold
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-06-01
coleção:BMC Medicine
Assuntos:
Neurodegenerative disease
Cerebrospinal fluid
Biomarkers
Prion
Primary prevention
Clinical trial design
Acesso em linha:http://link.springer.com/article/10.1186/s12916-020-01608-8
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