Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation

Snail1 is a key factor controlling epithelial-to-mesenchymal transition and cancer metastasis. While the E3 ligases responsible for Snail1 ubiquitination and degradation have been defined, the deubiquitinating enzyme is unknown. Here Zhou and colleagues show that Dub3 stabilizes Snail1 by removing u...

Description complète

Détails bibliographiques

Auteurs principaux:	Yadi Wu, Yu Wang, Yiwei Lin, Yajuan Liu, Yifan Wang, Jianhang Jia, Puja Singh, Young-In Chi, Chi Wang, Chenfang Dong, Wei Li, Min Tao, Dana Napier, Qiuying Shi, Jiong Deng, B Mark Evers, Binhua P. Zhou
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2017-02-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/ncomms14228
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!