New non-toxic biocompatible dianionic ionic liquids that enhance the solubility of oral drugs from BCS class II

New dianionic ionic liquids (ILs) based on carboxylic anions and ammonium cations were prepared and characterized. They were used as excipients to increase the solubility of two model oral drugs of BCS class II, ibuprofen and piroxicam. With only 0.2 mol% (≈100 mM) of [N4 1 1 2OH]2[C4H4O4], the solu...

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Detalhes bibliográficos

Principais autores:	Daniela A.S. Agostinho, Filipa Santos, José M.S.S. Esperança, Ana R.C. Duarte, Patrícia M. Reis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-09-01
coleção:	Journal of Ionic Liquids
Assuntos:	Dianionic ionic liquids Cytotoxicity Drug delivery Bioavailability BCS Class II oral drugs
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2772422021000033
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