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Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species.

All tRNAs have numerous modifications, lack of which often results in growth defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In S. cerevisiae, lack of tRNA body modifications can lead to impaired tRNA stability and decay of a subset of the hypomod...

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Главные авторы: Monika Tasak, Eric M Phizicky
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science (PLoS) 2022-07-01
Серии:PLoS Genetics
Online-ссылка:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010215&type=printable
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