N-Halosuccinimide enables cascade oxidative trifluorination and halogenative cyclization of tryptamine-derived isocyanides

Abstract Both the pyrroloindoline core and N–CF3 moiety hold significant importance in medicinal chemistry. However, to date, no instances of constructing N–CF3-containing pyrroloindolines have been reported. Herein, we present a robust and operationally simple approach to assembling such intriguing...

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Autors principals:	Jun-Yunzi Wu, Long-Ling Huang, Jia-Luo Fu, Jia-Yi Li, Shuang Lin, Shuang Yang, Zhi-Shu Huang, Honggen Wang, Qingjiang Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-10-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-024-53271-9
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