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DeepCBS: shedding light on the impact of mutations occurring at CTCF binding sites

CTCF-mediated chromatin loops create insulated neighborhoods that constrain promoter-enhancer interactions, serving as a unit of gene regulation. Disruption of the CTCF binding sites (CBS) will lead to the destruction of insulated neighborhoods, which in turn can cause dysregulation of the contained...

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Principais autores: Yiheng Wang, Xingli Guo, Zhixin Niu, Xiaotai Huang, Bingbo Wang, Lin Gao
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2024-02-01
סדרה:Frontiers in Genetics
נושאים:
CTCF
insulated neighborhoods
liver cancer
proto-oncogene
deep learning
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fgene.2024.1354208/full
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