Efficacy and safety of peripherally-restricted κ-opioid receptor agonist-HSK21542 for postoperative analgesia in patients undergoing laparoscopic abdominal surgery: a randomized, placebo-controlled phase 2 trial

BackgroundThis phase 2 trial comprised dose exploration (stage 1) and dose confirmation stages (stage 2) to determine the safety and efficacy of HSK21542 in patients undergoing laparoscopic abdominal surgery.MethodsIn stage 1, patients were randomly allocated at a ratio of 4:1 (12 to receive HSK2154...

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Detalhes bibliográficos

Principais autores:	Yinbo Zhong, Haiying Wang, Min Yan, Mengchang Yang, Jiaqiang Zhang, Ling Nan, Zhiping Wang, Jianjun Yang, Jinglei Wu, Qulian Guo, Xiaoling Hu, Hongmeng Xu, Qiang Xu, Dongxin Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-07-01
coleção:	Frontiers in Medicine
Assuntos:	κ-opioid receptor agonists postoperative analgesia laparoscopic abdominal surgery HSK21542 time-weighted summed pain intensity difference
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1604790/full
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