A cross-tissue transcriptome-wide association study identifies novel candidate genes associated with brain glymphatic system function

Abstract The glymphatic system plays a key role in brain waste clearance, but its genetic regulation remains poorly understood. Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) index is a non-invasive imaging biomarker to asses glymphatic system activity. We integrated mean DT...

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Bibliografiska uppgifter

Huvudupphov:	Xiaoyang Zhu, Shengjie Wang, Shuaiqi Zhang, Zhiyuan Liu, Na Wang, Shu Wang, Nixia Yang
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-12-01
Serie:	Molecular Brain
Ämnen:	Glymphatic system Cross-tissue TWAS UTMOST Colocalization Mendelian randomization DTI-ALPS
Länkar:	https://doi.org/10.1186/s13041-025-01258-y
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