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The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila.

Alzheimer's (AD) is a progressive neurodegenerative disease that afflicts a significant fraction of older individuals. Although a proteolytic product of the Amyloid precursor protein, the Alphabeta42 polypeptide, has been directly implicated in the disease, the genes and biological pathways that are...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Lihua Tan, Paul Schedl, Ho-Juhn Song, Dan Garza, Mary Konsolaki
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Public Library of Science (PLoS) 2008-01-01
Цуврал:PLoS ONE
Онлайн хандалт:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19088848/?tool=EBI
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