Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies

Highlights Females show a significant increase in the expression of MED31 in the frontal cortex. This gene is involved in lipid metabolism and neural diseases. We found 237 genes having sex-based significantly differential expression in substantia nigra. Functional profiling of these genes reveals a...

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Hlavní autoři:	Adolfo López-Cerdán, Zoraida Andreu, Marta R. Hidalgo, Rubén Grillo-Risco, José Francisco Català-Senent, Irene Soler-Sáez, Almudena Neva-Alejo, Fernando Gordillo, María de la Iglesia-Vayá, Francisco García-García
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2022-11-01
Edice:	Biology of Sex Differences
Témata:	Parkinson disease Sex differences Meta-analysis Transcriptomics Neurodegeneration
On-line přístup:	https://doi.org/10.1186/s13293-022-00477-5
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