Kinetic Analysis of SARS-CoV-2 S1–Integrin Binding Using Live-Cell, Label-Free Optical Biosensing

The SARS-CoV-2 spike (S1) protein facilitates viral entry through binding to angiotensin-converting enzyme 2 (ACE2), but it also contains an Arg–Gly–Asp (RGD) motif that may enable interactions with RGD-binding integrins on ACE2-negative cells. Here, we provide quantitative evidence for this alterna...

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Main Authors: Nicolett Kanyo, Krisztina Borbely, Beatrix Peter, Kinga Dora Kovacs, Anna Balogh, Beatrix Magyaródi, Sandor Kurunczi, Inna Szekacs, Robert Horvath
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-08-01
Serier:Biosensors
Fag:
SARS-CoV-2 spike protein
integrin binding
RGD motif
label-free optical biosensing
resonant waveguide grating
HeLa cell adhesion
Online adgang:https://www.mdpi.com/2079-6374/15/8/534
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