Lipofuscin autofluorescence confounds intracellular amyloid β detection in the aged mouse brain
Intracellular amyloid β (Aβ) accumulation is a contentious feature of Alzheimer’s disease (AD), increasingly reported in young adults and aged animal models of AD. However, autofluorescent lipofuscin granules which consist of a mixture of highly oxidized lipids, misfolded proteins, and metals, accum...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2025-01-01
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| coleção: | Aging Brain |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2589958925000143 |
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