The physiological limits of bispecific monoclonal antibody tissue targeting specificity

Bispecific monoclonal antibodies (bsmAbs) are expected to provide targeted drug delivery that overcomes the dose-limiting toxicities often accompanying antibody-drug conjugates (ADC) in clinical practice. Much attention has been paid in the past to target selection, mAb affinities and the payload li...

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Auteurs principaux:	Armin Sepp, Felix Stader, Abdallah Derbalah, Cong Liu, Adriana Zyla, Iain Gardner, Masoud Jamei
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis Group 2025-12-01
Collection:	mAbs
Sujets:	Monoclonal antibody bispecific antibody antibody-drug conjugate physiologically-based pharmacokinetics EGFR HER2
Accès en ligne:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2492236
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