The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.

Highly pathogenic H5N1 influenza A viruses have spread across Asia, Europe, and Africa. More than 500 cases of H5N1 virus infection in humans, with a high lethality rate, have been reported. To understand the molecular basis for the high virulence of H5N1 viruses in mammals, we tested the virulence...

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Autors principals:	Hirotaka Imai, Kyoko Shinya, Ryo Takano, Maki Kiso, Yukiko Muramoto, Saori Sakabe, Shin Murakami, Mutsumi Ito, Shinya Yamada, Mai Thi Quynh Le, Chairul A Nidom, Yuko Sakai-Tagawa, Kei Takahashi, Yasuyuki Omori, Takeshi Noda, Masayuki Shimojima, Satoshi Kakugawa, Hideo Goto, Kiyoko Iwatsuki-Horimoto, Taisuke Horimoto, Yoshihiro Kawaoka
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2010-01-01
Col·lecció:	PLoS Pathogens
Accés en línia:	http://europepmc.org/articles/PMC2940759?pdf=render
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