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A critical reappraisal of neutrophil extracellular traps (NETs) and NETosis mimics based on differential requirements for protein citrullination

NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic lupus erythematosus (SLE). Activation of the citrullinating enzyme peptidylarginine deiminase type 4 (PAD4) is believed t...

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Principais autores: Maximilian Ferdinand Konig, Felipe Andrade
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016-11-01
Serier:Frontiers in Immunology
Fag:
Mitochondria
NADPH Oxidase
Neutrophil
Rheumatoid arthritis
mitophagy
ROS
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00461/full
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