Ensemble of structure and ligand-based classification models for hERG liability profiling

Drug-induced cardiotoxicity represents one of the most critical safety concerns in the early stages of drug development. The blockade of the human ether-à-go-go-related potassium channel (hERG) is the most frequent cause of cardiotoxicity, as it is associated to long QT syndrome which can lead to fa...

Descripción completa

Detalles Bibliográficos

Autores principales:	Serena Vittorio, Filippo Lunghini, Alessandro Pedretti, Giulio Vistoli, Andrea R. Beccari
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2023-03-01
Colección:	Frontiers in Pharmacology
Materias:	hERG cardiotoxicity predictive toxicology machine learning random forest docking
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1148670/full
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!