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Understanding the glioblastoma tumor microenvironment: leveraging the extracellular matrix to increase immunotherapy efficacy

Glioblastoma (GBM) accounts for approximately half of all malignant brain tumors, and it remains lethal with a five-year survival of less than 10%. Despite the immense advancements in the field, it has managed to evade even the most promising therapeutics: immunotherapies. The main reason is the hig...

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Principais autores: Jimena Collado, Lauren Boland, Jared T. Ahrendsen, Jason Miska, Catalina Lee-Chang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-02-01
Serier:Frontiers in Immunology
Fag:
glioblastoma
extracellular matrix
tumor microenvironment
immunotherapy
cancer-associated fibroblasts
fibronectin
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1336476/full
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