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A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis

Abstract Lynch syndrome (LS), the most common inherited colorectal cancer (CRC) syndrome, increases the cancer risk in affected individuals. LS is caused by pathogenic germline variants in one of the DNA mismatch repair (MMR) genes, complete inactivation of which causes numerous mutations in affecte...

Celý popis

Uloženo v:
Hlavní autoři: Saskia Haupt, Nils Gleim, Aysel Ahadova, Hendrik Bläker, Magnus vonKnebel Doeberitz, Matthias Kloor, Vincent Heuveline
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley 2021-06-01
Edice:Computational and Systems Oncology
Témata:
Colonic Crypts
Colorectal Cancer
Carcinogenesis
Lynch Syndrome
Computational Modeling
Voronoi Tessellation Model
On-line přístup:https://doi.org/10.1002/cso2.1020
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