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Expanding the horizon of CAR T cell therapy: from cancer treatment to autoimmune diseases and beyond

Chimeric antigen receptor (CAR)-T-cell therapy has garnered significant attention for its transformative impact on the treatment of hematologic malignancies such as leukemia and lymphoma. Despite its remarkable success, challenges such as resistance, limited efficacy in solid tumors, and adverse sid...

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Main Authors: Zishan Yang, Bingjun Ha, Qinhan Wu, Feng Ren, Zhinan Yin, Hongru Zhang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
CAR-T cells
adoptive immunotherapy
tumor microenvironment
solid tumors
autoimmune diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544532/full
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