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Heterogeneity of resistant mechanisms in an EGFR-TKI relapsed patient with EGFR amplification and response to nimotuzumab: A case report

EGFR mutations are the most important drivers of gene alterations in lung adenocarcinomas and are sensitive to EGFR-TKIs. However, resistance to EGFR-TKIs is inevitable in the majority of EGFR-mutated lung cancer patients. Numerous resistant mechanisms have been revealed to date, and more are still...

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Principais autores: Yan Li, Ziyi Xu, Tongji Xie, Puyuan Xing, Jianming Ying, Junling Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-08-01
coleção:Frontiers in Oncology
Assuntos:
case report
resistance
heterogeneity
EGFR amplification
nimotuzumab
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2022.937282/full
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