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Effect of CYP3A4, CYP3A5, MDR1 and POR Genetic Polymorphisms in Immunosuppressive Treatment in Chilean Kidney Transplanted Patients

Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms in genes related to the metabolism and transport of these drugs, namely CYP3A4, CYP3A5, MDR1 and POR genes, has been evalu...

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Principais autores: Stephania Contreras-Castillo, Anita Plaza, Jana Stojanova, Gustavo Navarro, Rodolfo Carmona, Fernando Corvalán, Leslie Cerpa, Christopher Sandoval, Daniel Muñoz, Marina Leiva, Luis E. Castañeda, Nayaret Farias, Carolina Alvarez, Gabriel Llull, Sergio Mezzano, Leopoldo Ardiles, Nelson Varela, María S. Rodríguez, Claudio Flores, Juan Pablo Cayún, Paola Krall, Luis A. Quiñones
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-12-01
coleção:Frontiers in Pharmacology
Assuntos:
polymorphisms
pharmacogenetics
kidney transplant
cyclosporine
tacrolimus
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2021.674117/full
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