Comparative proteomic analysis of colorectal cancer stem cells reveals potential biomarkers and altered pathways

BackgroundColorectal cancer (CRC) initiating/stem cells (CICs/CSCs) represent a rare tumor subpopulation with self-renewal capacity that drives tumor progression, recurrence, therapeutic resistance, and immune evasion. Despite extensive efforts to define CSCs using surface and functional markers, no...

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Detalhes bibliográficos

Principais autores:	Ola J. Hussein, Lubna Therachiyil, Shahd M. Younis, Shaymaa Itani, Hanan H. Abunada, Issam Tout, Cristina Maccalli, Hesham M. Korashy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Molecular Biosciences
Assuntos:	cancer stem cells cancer-initiating cells colorectal cancer LC-MS/MS proteomics spheroids
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmolb.2026.1801265/full
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