Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes

A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization. Here, we find that DNA methylation of the TERT CpG island (CGI) is also allele-speci...

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Detalhes bibliográficos

Principais autores:	Josh Lewis Stern, Richard D. Paucek, Franklin W. Huang, Mahmoud Ghandi, Ronald Nwumeh, James C. Costello, Thomas R. Cech
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-12-01
coleção:	Cell Reports
Assuntos:	telomerase TERT promoter Polycomb repressive complex 2 PRC2 5-methylcytosine allele-specific monoallelic CpG island cancer
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124717317977
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