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Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid

Abstract Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular h...

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Principais autores: Annett Mikolasch, Elke Hammer, Sabine Witt, Ulrike Lindequist
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2020-10-01
Serier:AMB Express
Fag:
Laccase
Biotransformation
ß-lactam antibiotics
Antibacterial activity
Online adgang:http://link.springer.com/article/10.1186/s13568-020-01117-0
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