Repurposing flufenamic acid as a putative PmrB-directed adjuvant to restore colistin activity in Klebsiella pneumoniae
ABSTRACT Antimicrobial resistance in gram-negative bacteria has renewed reliance on colistin, yet resistance to this last-line agent is increasing. In Klebsiella pneumoniae, activation of the PmrA/PmrB two-component system remodels lipid A and reduces colistin binding, motivating the sensor kinase P...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
American Society for Microbiology
2026-04-01
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| سلاسل: | Microbiology Spectrum |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://journals.asm.org/doi/10.1128/spectrum.03620-25 |
| الوسوم: |
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